Keener et al., Validation of human telomere length trans-ancestry meta-analysis association signals identifies POP5 and KBTBD6 as novel human telomere length regulation genes. (2023). https://doi.org/10.1101/2023.07.12.548702

Chun-On P, Hinchie AM, Beale HC, Gil Silva AA, Rush E, Sander C, Connelly CJ, Seynnaeve BKN, Kirkwood JM, Vaske OM, Greider CW, Alder JK. (2022) TPP1 promoter mutations cooperate with TERT promoter mutations to lengthen telomeres in melanoma. Science, 2022. https://doi.org/10.1126/science.abq0607

Sholes, S.L., Karimian, K., Gershman, A., Kelly, T.J., Timp, W., and Greider, C.W. (2021). Chromosome-specific telomere lengths and the minimal functional telomere revealed by nanopore sequencing. Genome Res. https://doi.org/10.1101/gr.275868.121

Connelly, C.J., Vidal-Cardenas, S., Goldsmith, S., and Greider, C.W. (2021). The Bur1 cyclin-dependent kinase regulates telomere length in Saccharomyces cerevisiae. Yeast. https://doi.org/10.1002/yea.3680

Shubin, C.B., Mayangsari, R., Swett, A.D., and Greider, C.W. (2021). Rif1 regulates telomere length through conserved HEAT repeats. Nucleic Acids Res 49, 3967-3980. https://doi.org/10.1093/nar/gkab206

Shubin, C.B., and Greider, C.W. (2020). The role of Rif1 in telomere length regulation is separable from its role in origin firing. eLife 9. https://doi.org/10.7554/eLife.58066

Keener, R., Connelly, C.J., and Greider, C.W. (2019). Tel1 Activation by the MRX Complex Is Sufficient for Telomere Length Regulation but Not for the DNA Damage Response in Saccharomyces cerevisiae. Genetics 213, 1271-1288. https://doi.org/10.1534/genetics.119.302713

Alder, J.K., Hanumanthu, V.S., Strong, M.A., DeZern, A.E., Stanley, S.E., Takemoto, C.M., Danilova, L., Applegate, C.D., Bolton, S.G., Mohr, D.W., et al. (2018). Diagnostic utility of telomere length testing in a hospital-based setting. Proc Natl Acad Sci U S A 115, E2358-E2365. https://doi.org/10.1073/pnas.1720427115

Lee, S.S., Bohrson, C., Pike, A.M., Wheelan, S.J., and Greider, C.W. (2015). ATM Kinase Is Required for Telomere Elongation in Mouse and Human Cells. Cell reports 13, 1623-1632. https://doi.org/10.1016/j.celrep.2015.10.035

Kaizer, H., Connelly, C.J., Bettridge, K., Viggiani, C., and Greider, C.W. (2015). Regulation of Telomere Length Requires a Conserved N-Terminal Domain of Rif2 in Saccharomyces cerevisiae. Genetics 201, 573-586. https://doi.org/10.1534/genetics.115.177899

Bender, H.S., Murchison, E.P., Pickett, H.A., Deakin, J.E., Strong, M.A., Conlan, C., McMillan, D.A., Neumann, A.A., Greider, C.W., Hannon, G.J., et al. (2012). Extreme telomere length dimorphism in the Tasmanian devil and related marsupials suggests parental control of telomere length. PLoS One 7, e46195. https://doi.org/10.1371/journal.pone.0046195

Strong, M.A., Vidal-Cardenas, S.L., Karim, B., Yu, H., Guo, N., and Greider, C.W. (2011). Phenotypes in mTERT(+)/(-) and mTERT(-)/(-) mice are due to short telomeres, not telomere-independent functions of telomerase reverse transcriptase. Molecular and cellular biology 31, 2369-2379. https://doi.org/10.1128/MCB.05312-11

Vidal-Cardenas, S.L., and Greider, C.W. (2010). Comparing effects of mTR and mTERT deletion on gene expression and DNA damage response: a critical examination of telomere length maintenance-independent roles of telomerase. Nucleic Acids Res 38, 60-71. https://doi.org/gkp855 [pii] 10.1093/nar/gkp855

10.1186/1471-2091-11-45 

Tom, H.I., and Greider, C.W. (2010). A sequence-dependent exonuclease activity from Tetrahymena thermophila. BMC Biochem 11, 45. https://doi.org/1471-2091-11-45 [pii]

Morrish, T.A., and Greider, C.W. (2009). Short telomeres initiate telomere recombination in primary and tumor cells. PLoS Genet 5, e1000357. https://doi.org/10.1371/journal.pgen.1000357

10.1128/MCB.01896-08 

Ma, Y., and Greider, C.W. (2009). Kinase-independent functions of TEL1 in telomere maintenance. Mol Cell Biol 29, 5193-5202. https://doi.org/MCB.01896-08 [pii]

Armanios, M.Y., Chen, J.J., Cogan, J.D., Alder, J.K., Ingersoll, R.G., Markin, C., Lawson, W.E., Xie, M., Vulto, I., Phillips, J.A., 3rd, et al. (2007). Telomerase mutations in families with idiopathic pulmonary fibrosis. N Engl J Med 356, 1317-1326. https://doi.org/10.1056/NEJMoa066157

Feldser, D.M., and Greider, C.W. (2007). Short telomeres limit tumor progression in vivo by inducing senescence. Cancer Cell 11, 461-469. https://doi.org/10.1016/j.ccr.2007.02.026

Armanios, M.Y., Chen, J.J., Cogan, J.D., Alder, J.K., Ingersoll, R.G., Markin, C., Lawson, W.E., Xie, M., Vulto, I., Phillips, J.A., 3rd, et al. (2007). Telomerase mutations in families with idiopathic pulmonary fibrosis. N Engl J Med 356, 1317-1326. 

Frank, C.J., Hyde, M., and Greider, C.W. (2006). Regulation of telomere elongation by the cyclin-dependent kinase CDK1. Mol Cell 24, 423-432. https://doi.org/10.1016/j.molcel.2006.10.020

Feldser, D., Strong, M.A., and Greider, C.W. (2006). Ataxia telangiectasia mutated (Atm) is not required for telomerase-mediated elongation of short telomeres. Proc Natl Acad Sci U S A 103, 2249-2251. https://doi.org/10.1073/pnas.0511143103

Hao, L.Y., Armanios, M., Strong, M.A., Karim, B., Feldser, D.M., Huso, D., and Greider, C.W. (2005). Short telomeres, even in the presence of telomerase, limit tissue renewal capacity. Cell 123, 1121-1131. https://doi.org/10.1016/j.cell.2005.11.020

Chen, J.L., and Greider, C.W. (2005). Functional analysis of the pseudoknot structure in human telomerase RNA. Proc Natl Acad Sci U S A 102, 8080-8085; discussion 8077-8089. https://doi.org/10.1073/pnas.0502259102

Armanios, M., Chen, J.L., Chang, Y.P., Brodsky, R.A., Hawkins, A., Griffin, C.A., Eshleman, J.R., Cohen, A.R., Chakravarti, A., Hamosh, A., et al. (2005). Haploinsufficiency of telomerase reverse transcriptase leads to anticipation in autosomal dominant dyskeratosis congenita. Proc Natl Acad Sci U S A 102, 15960-15964. https://doi.org/10.1073/pnas.0508124102

Hao, L.Y., Strong, M.A., and Greider, C.W. (2004). Phosphorylation of H2AX at short telomeres in T cells and fibroblasts. J Biol Chem 279, 45148-45154. https://doi.org/10.1074/jbc.M403924200

Hao, L.Y., and Greider, C.W. (2004). Genomic instability in both wild-type and telomerase null MEFs. Chromosoma 113, 62-68. https://doi.org/10.1007/s00412-004-0291-7

Qi, L., Strong, M.A., Karim, B.O., Armanios, M., Huso, D.L., and Greider, C.W. (2003). Short telomeres and ataxia-telangiectasia mutated deficiency cooperatively increase telomere dysfunction and suppress tumorigenesis. Cancer Res 63, 8188-8196. 

Mason, D.X., Goneska, E., and Greider, C.W. (2003). Stem-loop IV of tetrahymena telomerase RNA stimulates processivity in trans. Mol Cell Biol 23, 5606-5613. https://doi.org/10.1128/MCB.23.16.5606-5613.2003

IJpma, A., and Greider, C.W. (2003). Short telomeres induce a DNA damage response in Saccharomyces cerevisiae. Mol Biol Cell 14, 987-1001. https://doi.org/10.1091/mbc.02-04-0057

Hackett, J.A., and Greider, C.W. (2003). End resection initiates genomic instability in the absence of telomerase. Mol Cell Biol 23, 8450-8461. https://doi.org/10.1128/MCB.23.23.8450-8461.2003

Feldser, D.M., Hackett, J., and Greider, C.W. (2003). Telomere dysfunction and the initiation of genome instability. Nature Reviews Cancer 3, 623-627. 

Chen, J.L., and Greider, C.W. (2003). Template boundary definition in mammalian telomerase. Genes Dev 17, 2747-2752. 

Chen, J.-L., and Greider, C.W. (2003). Determinants in mammalian telomerase RNA that mediate enzyme processivity and cross-species incompatibility. Embo J 22, 304-314. 

Hathcock, K.S., Hemann, M.T., Opperman, K.K., Strong, M.A., Greider, C.W., and Hodes, R.J. (2002). Haploinsufficiency of mTR results in defects in telomere elongation. Proc Natl Acad Sci U S A 99, 3591-3596. https://doi.org/10.1073/pnas.012549799

Chen, J.L., Opperman, K.K., and Greider, C.W. (2002). A critical stem-loop structure in the CR4-CR5 domain of mammalian telomerase RNA. Nucleic Acids Res 30, 592-597. https://doi.org/10.1093/nar/30.2.592

Mason, D.X., Autexier, C., and Greider, C.W. (2001). Tetrahymena proteins p80 and p95 are not core telomerase components. Proc Natl Acad Sci U S A 98, 12368-12373. https://doi.org/10.1073/pnas.221456398

Hemann, M.T., Strong, M.A., Hao, L.-Y., and Greider, C.W. (2001). The Shortest Telomere, Not Average Telomere Length, Is Critical for Cell Viability and Chromosome Stability. Cell 107, 67-77. https://doi.org/10.1016/s0092-8674(01)00504-9

Hemann, M.T., Rudolph, K.L., Strong, M.A., DePinho, R.A., Chin, L., and Greider, C.W. (2001). Telomere dysfunction triggers developmentally regulated germ cell apoptosis. Mol Biol Cell 12, 2023-2030. https://doi.org/10.1091/mbc.12.7.2023

Hackett, J.A., Feldser, D.M., and Greider, C.W. (2001). Telomere dysfunction increases mutation rate and genomic instability. Cell 106, 275-286. https://doi.org/10.1016/s0092-8674(01)00457-3

Chen, Q., Ijpma, A., and Greider, C.W. (2001). Two survivor pathways that allow growth in the absence of telomerase are generated by distinct telomere recombination events. Mol Cell Biol 21, 1819-1827. https://doi.org/10.1128/MCB.21.5.1819-1827.2001

Le, S., Sternglanz, R., and Greider, C.W. (2000). Identification of two RNA-binding proteins associated with human telomerase RNA. Mol Biol Cell 11, 999-1010. https://doi.org/10.1091/mbc.11.3.999

Hemann, M.T., and Greider, C.W. (2000). Wild-derived inbred mouse strains have short telomeres. Nucleic Acids Res 28, 4474-4478. https://doi.org/10.1093/nar/28.22.4474

Chen, J.L., Blasco, M.A., and Greider, C.W. (2000). Secondary structure of vertebrate telomerase RNA. Cell 100, 503-514. https://doi.org/10.1016/s0092-8674(00)80687-x

Le, S., Moore, J.K., Haber, J.E., and Greider, C.W. (1999). RAD50 and RAD51 define two pathways that collaborate to maintain telomeres in the absence of telomerase. Genetics 152, 143-152. https://doi.org/10.1093/genetics/152.1.143

Hemann, M.T., and Greider, C.W. (1999). G-strand overhangs on telomeres in telomerase-deficient mouse cells. Nucleic Acids Res 27, 3964-3969. https://doi.org/10.1093/nar/27.20.3964

Greenberg, R.A., Chin, L., Femino, A., Lee, K.H., Gottlieb, G.J., Singer, R.H., Greider, C.W., and DePinho, R.A. (1999). Short dysfunctional telomeres impair tumorigenesis in the INK4a(delta2/3) cancer-prone mouse. Cell 97, 515-525. https://doi.org/10.1016/s0092-8674(00)80761-8

Chin, L., Artandi, S.E., Shen, Q., Tam, A., Lee, S.L., Gottlieb, G.J., Greider, C.W., and DePinho, R.A. (1999). p53 deficiency rescues the adverse effects of telomere loss and cooperates with telomere dysfunction to accelerate carcinogenesis. Cell 97, 527-538. https://doi.org/10.1016/s0092-8674(00)80762-x

Lee, H.W., Blasco, M.A., Gottlieb, G.J., Horner, J.W., 2nd, Greider, C.W., and DePinho, R.A. (1998). Essential role of mouse telomerase in highly proliferative organs. Nature 392, 569-574. https://doi.org/10.1038/33345

Hinkley, C.S., Blasco, M.A., Funk, W.D., Feng, J., Villeponteau, B., Greider, C.W., and Herr, W. (1998). The mouse telomerase RNA 5"-end lies just upstream of the telomerase template sequence. Nucleic Acids Res 26, 532-536. https://doi.org/10.1093/nar/26.2.532

Autexier, C., and Greider, C.W. (1998). Mutational analysis of the Tetrahymena telomerase RNA: identification of residues affecting telomerase activity in vitro. Nucleic Acids Res 26, 787-795. https://doi.org/10.1093/nar/26.3.787

Blasco, M.A., Lee, H.W., Hande, M.P., Samper, E., Lansdorp, P.M., DePinho, R.A., and Greider, C.W. (1997). Telomere shortening and tumor formation by mouse cells lacking telomerase RNA. Cell 91, 25-34. https://doi.org/10.1016/s0092-8674(01)80006-4

Buchkovich, K.J., and Greider, C.W. (1996). Telomerase regulation during entry into the cell cycle in normal human T cells. Mol Biol Cell 7, 1443-1454. https://doi.org/10.1091/mbc.7.9.1443

Blasco, M.A., Rizen, M., Greider, C.W., and Hanahan, D. (1996). Differential regulation of telomerase activity and telomerase RNA during multi-stage tumorigenesis. Nat Genet 12, 200-204. https://doi.org/10.1038/ng0296-200

Avilion, A.A., Piatyszek, M.A., Gupta, J., Shay, J.W., Bacchetti, S., and Greider, C.W. (1996). Human telomerase RNA and telomerase activity in immortal cell lines and tumor tissues. Cancer Res 56, 645-650. 

Autexier, C., Pruzan, R., Funk, W.D., and Greider, C.W. (1996). Reconstitution of human telomerase activity and identification of a minimal functional region of the human telomerase RNA. EMBO J 15, 5928-5935. https://doi.org/10.1002/j.1460-2075.1996.tb00979.x

Prowse, K.R., and Greider, C.W. (1995). Developmental and tissue-specific regulation of mouse telomerase and telomere length. Proc Natl Acad Sci U S A 92, 4818-4822. https://doi.org/10.1073/pnas.92.11.4818

Collins, K., and Greider, C.W. (1995). Utilization of ribonucleotides and RNA primers by Tetrahymena telomerase. EMBO J 14, 5422-5432. https://doi.org/10.1002/j.1460-2075.1995.tb00226.x

Blasco, M.A., Funk, W., Villeponteau, B., and Greider, C.W. (1995). Functional characterization and developmental regulation of mouse telomerase RNA. Science 269, 1267-1270. https://doi.org/10.1126/science.7544492

Feng, J., Funk, W.D., Wang, S.-S., Weinrich, S.L., Avilion, A.A., Chiu, C.-P., Adams, R.R., Chang, E., Allsopp, R.C., Yu, J., et al. (1995). The RNA component of human telomerase. Science 269, 1236-1241. https://doi.org/10.1126/science.7544491

Autexier, C., and Greider, C.W. (1995). Boundary elements of the Tetrahymena telomerase RNA template and alignment domains. Genes Dev 9, 2227-2239. https://doi.org/10.1101/gad.9.18.2227

Mantell, L.L., and Greider, C.W. (1994). Telomerase activity in germline and embryonic cells of Xenopus. EMBO J 13, 3211-3217. https://doi.org/10.1002/j.1460-2075.1994.tb06620.x

Autexier, C., and Greider, C.W. (1994). Functional reconstitution of wild-type and mutant Tetrahymena telomerase. Genes Dev 8, 563-575. https://doi.org/10.1101/gad.8.5.563

Prowse, K.R., Avilion, A.A., and Greider, C.W. (1993). Identification of a nonprocessive telomerase activity from mouse cells. Proc Natl Acad Sci U S A 90, 1493-1497. https://doi.org/10.1073/pnas.90.4.1493

Collins, K., and Greider, C.W. (1993). Tetrahymena telomerase catalyzes nucleolytic cleavage and nonprocessive elongation. Genes Dev 7, 1364-1376. https://doi.org/10.1101/gad.7.7b.1364

Levy, M.Z., Allsopp, R.C., Futcher, A.B., Greider, C.W., and Harley, C.B. (1992). Telomere end-replication problem and cell aging. J Mol Biol 225, 951-960. https://doi.org/10.1016/0022-2836(92)90096-3

Counter, C.M., Avilion, A.A., LeFeuvre, C.E., Stewart, N.G., Greider, C.W., Harley, C.B., and Bacchetti, S. (1992). Telomere shortening associated with chromosome instability is arrested in immortal cells which express telomerase activity. EMBO J 11, 1921-1929. https://doi.org/10.1002/j.1460-2075.1992.tb05245.x

Avilion, A.A., Harrington, L.A., and Greider, C.W. (1992). Tetrahymena telomerase RNA levels increase during macronuclear development. Dev Genet 13, 80-86. https://doi.org/10.1002/dvg.1020130113

Allsopp, R.C., Vaziri, H., Patterson, C., Goldstein, S., Younglai, E.V., Futcher, A.B., Greider, C.W., and Harley, C.B. (1992). Telomere length predicts replicative capacity of human fibroblasts. Proc Natl Acad Sci U S A 89, 10114-10118. https://doi.org/10.1073/pnas.89.21.10114

Harrington, L.A., and Greider, C.W. (1991). Telomerase primer specificity and chromosome healing. Nature 353, 451-454. https://doi.org/10.1038/353451a0

Greider, C.W. (1991). Telomerase is processive. Mol Cell Biol 11, 4572-4580. https://doi.org/10.1128/mcb.11.9.4572-4580.1991

Harley, C.B., Futcher, A.B., and Greider, C.W. (1990). Telomeres shorten during ageing of human fibroblasts. Nature 345, 458-460. https://doi.org/10.1038/345458a0

Blackburn, E.H., Greider, C.W., Henderson, E., Lee, M.S., Shampay, J., and Shippen-Lentz, D. (1989). Recognition and elongation of telomeres by telomerase. Genome 31, 553-560. https://doi.org/10.1139/g89-104

Greider, C.W., and Blackburn, E.H. (1987). The telomere terminal transferase of Tetrahymena is a ribonucleoprotein enzyme with two kinds of primer specificity. Cell 51, 887-898. https://doi.org/10.1016/0092-8674(87)90576-9

Greider, C.W., and Blackburn, E.H. (1985). Identification of a specific telomere terminal transferase activity in Tetrahymena extracts. Cell 43, 405-413. https://doi.org/10.1016/0092-8674(85)90170-9