Selected Publications

Greider, C.W., and Blackburn, E.H. (1985). Identification of a specific telomere terminal transferase activity in Tetrahymena extracts. Cell 43: 405–413.

Greider, C.W., and Blackburn, E.H. (1989). A telomeric sequence in the RNA of Tetrahymena telomerase required for telomere repeat synthesis. Nature 337: 331–337.

Harley, C.B., Futcher, A.B., and Greider, C.W. (1990). Telomeres shorten during ageing of human fibroblasts. Nature 345: 458–460.

Autexier, C., and Greider, C.W. (1995). Boundary elements of the Tetrahymena telomerase RNA template and alignment domains. Genes & Dev. 9: 2227-2239.

Blasco, M.A., Funk, W., Villeponteau, B., and Greider, C.W. (1995). Functional characterization and developmental regulation of the mouse telomerase RNA. Science 269: 1267-1270.

Prowse, K.R., and Greider, C.W. (1995). Developmental and tissue specific regulation of mouse telomerase and telomere length. Proc. Natl. Acad. Sci. U.S.A. 92: 4818-4822.

Blasco, M.A., Lee, H.-W., Hande, P.M., Samper, E., Lansdorp, P.M., DePinho, R.A., and Greider, C.W. (1997). Telomere shortening and tumor formation by mouse cells lacking telomerase RNA. Cell 91: 25-34.

Lee, H.-W., Blasco, M.A., Gottlieb, G.J., Horner, J.W., Greider, C.W., and DePinho, R.A. (1998). Essential role of mouse telomerase in highly proliferative organs. Nature 392: 569-574.

Chen, J.-L., Blasco, M., and Greider, C.W. (2000). A Secondary structure of vertebrate telomerase RNA. Cell 100: 503-514.

Hemann, M. T., Rudolph, L., Strong, M., DePinho, R. A., Chin, L., and Greider, C. W. (2001). Telomere dysfunction triggers developmentally regulated germ cell apoptosis. Mol. Biol. Cell. 12: 2023-2030.

Hackett, J., Feldser, D.M., and Greider, C. W. (2001). Telomere dysfunction increases mutation rate and genomic instability. Cell 106: 275-286.

Hemann, M. T., Strong, M., Hao, L.-Y., and Greider, C. W. (2001). The shortest telomere, not average telomere length, is critical for cell viability and chromosome stability. Cell 107: 66-77.

IJpma, A., and Greider, C.W. (2003). Short telomeres induce a DNA damage response in S. cerevisiae. Mol. Biol. Cell 14: 987-1001.

Chen, J.-L., and Greider, C.W. (2003) Template boundary definition in mammalian telomerase. Genes Dev. 17: 2747-2752.

Chen, J.-L., and Greider, C. W. (2005). Functional analysis of the pseudoknot structure in human telomerase RNA. Proc. Natl. Acad. Sci. U.S.A. 102: 8080-8085.

Armanios, M., Chen, J.-L., Chang, C. C., Brodsky, R. A., Hawkins, A., Griffen, C. A., J.R., E., Cohen, A. R., Chakravarti, A., Hamosh, A., and Greider, C. W. (2005). Haploinsufficiency of hTERT leads to anticipation in autosomal dominant dyskeratosis congenita. Proc. Natl. Acad. Sci. U.S.A. 102: 15960-15964.

Hao, L. Y., Armanios, M., Strong, M. A., Karim, B., Feldser, D. M., Huso, D., and Greider, C. W. (2005). Short Telomeres, even in the Presence of Telomerase, Limit Tissue Renewal Capacity. Cell 123: 1121-1131.

Feldser, D., and Greider, C. W. (2007). Short telomeres limit tumor progression in vivo by inducing senescence. Cancer Cell: 11, 461-469.

Reviews

Greider, C.W. (1990). Telomeres, telomerase and senescence. BioEssays 12: 363–369.

Greider, C.W. (1996). Telomere length regulation. Ann. Rev. Biochem. 65: 337-365.

Greider, C.W. (1998). Telomerase activity, cell proliferation and cancer. Proc. Natl. Acad. Sci. U.S.A. 95: 90-92.

Greider, C.W. (2001) Cellular responses to telomere shortening: cellular senescence as a tumor suppressor mechanism. Harvey Lect: 96:33-50.

Greider, C.W., and Blackburn, E.H. (2004). Tracking telomerase. Cell S11: S83-S86.

Chen, J.L., and Greider, C.W. (2004). An emerging consensus for telomerase RNA structure. Proc. Natl. Acad. Sci. U.S.A. 101: 14683-14684.

Blackburn, E. H., Greider, C. W., and Szostak, J. W. (2006). Telomeres and telomerase: the path from maize, Tetrahymena and yeast to human cancer and aging. Nat. Med. 12, 1133-1138.

Greider, C.W. (2007) Telomerase RNA levels limit the telomere length equilibrium. Cold Spring Harbor Laboratory Symposium on Quantitative Biology. Vol. LXXI 225-229.